Familial Aggregation of Atrial Fibrillation
نویسندگان
چکیده
منابع مشابه
Familial aggregation of atrial fibrillation in Iceland.
AIMS To examine the heritability of atrial fibrillation (AF) in Icelanders, utilizing a nationwide genealogy database and population-based data on AF. AF is a disorder with a high prevalence, which has been known to cluster in families, but the heritability of the common form has not been well defined. METHODS AND RESULTS The study population included 5269 patients diagnosed since 1987 and ag...
متن کاملFamilial aggregation of atrial fibrillation: a study in Danish twins.
BACKGROUND Heritability may play a role in nonfamilial atrial fibrillation (AF). We hypothesized that a monozygotic (MZ) twin whose co-twin was diagnosed with AF would have an increased risk of the disease compared with a dizygotic (DZ) twin in the same situation. METHODS AND RESULTS A sample of 1137 same-sex twin pairs (356 MZ and 781 DZ pairs) in which one or both members were diagnosed wit...
متن کاملFamilial aggregation of lone atrial fibrillation in young persons.
OBJECTIVES This study investigated whether an individual's risk of developing lone atrial fibrillation (AF) before age 60 years is associated with lone AF in relatives. BACKGROUND Genetic factors may play a role in the development of lone AF. METHODS Using Danish national registers, a cohort was established of ~4 million persons born between 1950 and 2008, and those with a family history of...
متن کاملPrognosis in Familial Atrial Fibrillation
A trial fibrillation (AF) is a common arrhythmia associated with substantial morbidity and a markedly increased risk of ischemic stroke. It accounts for one third of all strokes in patients above the age of 65 and is also associated with an increased mortality. In recent years, risk models for AF prediction have been developed based on clinical and demographic variables. AF may also present as ...
متن کاملConnexin40 nonsense mutation in familial atrial fibrillation.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia associated with substantial morbidity and mortality. Genetic variants play important roles in the pathogenesis of AF. However, AF is a genetically heterogeneous disorder, and the genetic determinants in most patients with AF remain to be identified. In this study, the entire coding region of the connexin40 gene, encoding t...
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ژورنال
عنوان ژورنال: Circulation: Arrhythmia and Electrophysiology
سال: 2009
ISSN: 1941-3149,1941-3084
DOI: 10.1161/circep.108.786665